Brain-on-a-chip for understanding cortical circuit formation and function: a talk by Dr. Vincent Daria of Australian National University

Date: 
Monday, July 17, 2017
To: 
Monday, July 17, 2017
Time: 
11:00 AM
To: 
12:30 PM
Venue: 
CTC 118

The Department of Physics would like to invite you to the talk “Brain-on-a-chip for understanding cortical circuit formation and function” by Dr. Vincent Daria, Group Leader of Neurophotonics Laboratory at the Eccles Institute of Neuroscience of Australian National University to be held on 17 July 2017, Monday, 11:00 a.m. at CTC 118. 


Abstract. We aim to understand the formation and function of brain circuits by growing neurons on nanostructured semiconductor devices (a.k.a. Brain-on-a-chip). We artificially grow brain cells on a semiconductor wafer patterned with nanowire scaffolds. From a fundamental perspective, we aim to investigate the structural significance of nanoscale topographies for guiding neurite outgrowth. To correlate the circuit function on the neurons grown on-a-chip with that of certain areas in the brain, we need to analyse the function of single neurons and population of neurons forming circuits in living mammalian brain slices and that of an intact rodent brain. To achieve this, we use novel photonic technologies not only to visualize these neurons but also to stimulate and record neuronal activity to understand the input/output transfer function of neurons and circuits. Understanding neuronal and circuit function is in itself a grand challenge and has attracted major research thrusts worldwide. Hence, correlating the input-output transfer function of neuronal of circuits from both living brain and that of neurons grown on-a-chip can lead to new insights on how the brain functions during learning, memory and information processing.

Read more in Ateneo Physics News.